Product Usage: For Research Use Only – Not for Human or Veterinary Use
This product is not a drug, food, cosmetic, or dietary supplement and has not been evaluated by the FDA. It is strictly intended for in vitro research by qualified professionals. Any use in humans or animals is strictly prohibited and may violate federal, state, or local laws, including the Federal Food, Drug, and Cosmetic Act. No therapeutic or diagnostic application is implied or permitted. The purchaser assumes all responsibility for compliance with applicable regulations.
Dihexa Capsules
Capsule-form angiotensin IV analog studied in preclinical research for its interaction with synaptogenesis-related signaling pathways in the central nervous system. Supplied at research-grade purity for laboratory use only.
$275.00
Dihexa (PNB-0408) is a small-molecule oligopeptide derivative of angiotensin IV, developed by researchers at Washington State University to cross the blood-brain barrier and studied for its interaction with synaptogenesis-related signaling in preclinical cognitive-research models. The summary below reflects the published preclinical literature and is provided for research reference only — it does not describe an intended effect of this product in humans or animals.
What is Dihexa Capsules?
Dihexa is a peptide-based compound studied in laboratory research for its interaction with cellular signaling pathways within central nervous system-related biological systems. It was developed as a metabolically stabilized analog of angiotensin IV by the Harding-Wright research program, originally exploring compounds with pro-cognitive activity in aged and impaired rodent models. Its structure allows it to cross the blood–brain barrier, making it a subject of interest in studies focused on how compounds engage with complex biological systems at the cellular level. This compound is intended for research use only, and its applications outside of laboratory settings have not been established.
Chemical Identity
| CAS Number | 1401708-83-5 |
| Molecular Formula | C27H44N4O5 |
| Molecular Weight | 504.66 g/mol |
Full compound data: PubChem entry for Dihexa / PNB-0408.
Purity & Quality
First Class Science supplies Dihexa Capsules at 99% purity, verified by independent third-party HPLC testing and mass spectrometry. A Certificate of Analysis is available for every batch at https://firstclassscience.com/certificate-of-analysis/.
Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.
Important: This item is manufactured strictly for research purposes. It is not intended for human or veterinary use and is distributed solely for laboratory and scientific investigation.
Dihexa Research
Research Applications
Synaptogenesis & Cognitive Models
Research published by the Harding-Wright group reported that Dihexa increased dendritic spine density in cultured hippocampal neurons, describing its potency in these synaptogenesis assays as exceeding that of brain-derived neurotrophic factor (BDNF) by several orders of magnitude in the tested system. Related studies in scopolamine-impaired and aged rat models reported improved performance on cognitive-task measures following dosing.
Proposed Mechanism
The leading hypothesis proposes that Dihexa acts through the hepatocyte growth factor (HGF) / c-Met receptor system, a growth-factor pathway associated with formation of new dendritic spines and synapses in tested neuron cultures; blocking this pathway has been reported to eliminate the spine-density effect in those models. Researchers note that the original paper proposing direct HGF binding was later retracted, so this mechanism is best treated by researchers as a working hypothesis rather than an established fact.
Disclaimer: The research summarized above is drawn from third-party published studies conducted in animal, in vitro, or non-U.S. clinical contexts. It is provided for research and educational reference only and does not describe an intended use, effect, or benefit of this product for any person or animal.
⊗ ALL ITEMS ARE SOLD FOR RESEARCH USE ONLY. This category covers strictly in vitro laboratory testing and scientific experimentation. Content on this site is for education only and does not authorize human or animal use of any kind, which is prohibited by law. Only trained, licensed professionals should handle these materials. Nothing sold here qualifies as a drug, food, or cosmetic, and none of it may be labeled, advertised, or used as such.