Epithalon (Epitalon) – 50mg

Researchers who buy Epithalon (Epitalon) research peptide are typically studying its behavior as a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on the amino-acid composition of epithalamin, a bovine pineal-gland extract studied by Russian researchers for several decades. Epithalon is one of the most extensively published peptides in the geroscience/longevity-research literature, primarily in connection with telomerase activity. The summary below reflects the published preclinical literature and is provided strictly for research and educational reference — it does not describe an intended effect of this product in humans or animals.

In this reference:

• What Is Epithalon?
• Proposed Mechanism of Action
• Chemical Identity
• Purity, Storage & Quality
• Research Applications
• What the Human Evidence Shows
• Frequently Asked Questions

What Is Epithalon?

Epithalon (also written Epitalon or Epithalone; sequence Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed to model the amino-acid composition of epithalamin, a polypeptide extract from the bovine pineal gland studied extensively by Russian researchers V.K. Khavinson and V.N. Anisimov and colleagues over more than two decades. A 2026 peer-reviewed overview describes Epitalon as a “highly bioactive pineal tetrapeptide” studied via in vitro, in vivo, and in silico methods, with reported geroprotective and neuroendocrine research findings attributed to antioxidant, neuroprotective, and antimutagenic activity in tested models (Int J Mol Sci. 2026; PMID 40141333).

Researchers sourcing this compound are typically studying telomerase biology, pineal-gland/melatonin-pathway signaling, or comparative geroscience research models — this page describes the published scientific literature and does not describe an intended anti-aging or longevity effect of this research-use-only product for any person or animal.

Proposed Mechanism of Action

The most extensively cited proposed mechanism for Epithalon is modulation of telomerase activity. Published research has reported that Epitalon increases telomere length in tested human cell lines, with study authors proposing both telomerase-upregulation and alternative-lengthening-of-telomeres (ALT) pathway activity as candidate mechanisms depending on the cell-line model tested. Separate published research has examined Epitalon’s proposed influence on melatonin synthesis, interleukin-2 mRNA expression, murine-thymocyte mitogenic activity, and the activity of several enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and telomerase itself.

No single unified mechanism has been exhaustively confirmed across every proposed research thread, and researchers should treat mechanistic statements in this section as findings specific to the cited study models. The telomerase/telomere-length research thread remains the most substantiated and most frequently cited mechanism in the current literature.

Chemical Identity

Sequence	Ala-Glu-Asp-Gly (AEDG)
Molecular Formula	C13H20N4O8
Molecular Weight	~348.3 g/mol
Sequence Length	4 amino acids (tetrapeptide)
Appearance	White to off-white lyophilized powder

Purity, Storage & Quality

First Class Science supplies this Epithalon research peptide vial at research-grade purity, verified by independent third-party HPLC testing and mass spectrometry. A Certificate of Analysis is available for every batch at our Certificate of Analysis page, listing the specific lot’s purity result, molecular-weight confirmation, and test date.

Store the lyophilized (freeze-dried) compound at −20°C for long-term stability. This vial must be reconstituted with bacteriostatic or sterile water before laboratory use; after reconstitution, refrigerate at 2–8°C and use within 4–6 weeks. Avoid repeated freeze-thaw cycles and prolonged exposure to light or room-temperature conditions, both of which are associated with accelerated peptide degradation in handling literature.

Important: This item is manufactured strictly for research purposes. It is not intended for human or veterinary use and is distributed solely for laboratory and scientific investigation.

Preparing Solutions for Laboratory Use

Laboratories reconstituting lyophilized Epithalon for in vitro or animal-model research typically follow standard peptide-handling practice: the vial is brought to room temperature before opening, and a diluent — commonly reconstitution solution or sterile water for injection (SWFI) — is added slowly down the interior wall of the vial rather than directly onto the lyophilized material, to reduce foaming and mechanical stress on the peptide. The vial is then gently swirled, never shaken, until the powder is fully dissolved.

Stock-solution concentration for a given protocol is calculated by dividing the total peptide mass in the vial by the volume of diluent added, and that calculation should be recorded in the study’s protocol documentation. This page describes general laboratory reconstitution practice for research use and is not a dosing guide for human or animal administration.

Quality Control Methodology

Each production batch of this Epithalon research peptide undergoes independent third-party testing before release. High-performance liquid chromatography (HPLC) confirms purity by measuring the proportion of the target peptide relative to synthesis by-products or degradation fragments. Mass spectrometry separately confirms molecular identity, verifying that the measured mass of the material matches the expected ~348.3 g/mol molecular weight of Epithalon. Both results are recorded on the batch’s published Certificate of Analysis, letting researchers independently verify identity and purity rather than relying on manufacturer claims alone.

Who Should Buy Epithalon Research Peptide

Researchers who buy Epithalon from First Class Science are typically university and academic laboratories, contract research organizations (CROs), and biotechnology R&D teams running in vitro telomerase-activity assays or animal-model studies on geroscience and pineal-gland signaling research. First Class Science requires that all research-peptide orders be placed by parties who acknowledge and agree to the research-use-only terms stated on this page prior to purchase.

Research Applications

The published literature on Epithalon spans several distinct research areas. Each is summarized below strictly as a description of what has been studied in animal or in vitro models — not as a claim about effects for any individual using this product.

Telomerase and Telomere-Length Research

Published research has reported that Epitalon increases telomere length in tested human cell lines, with study authors examining both telomerase-upregulation and ALT-pathway mechanisms as candidate explanations. This is the most substantiated and most frequently cited research thread for this compound.

Animal-Model Lifespan and Geroscience Research

Published research by Anisimov and colleagues examined subcutaneous Epithalon administration in female SHR mice, reporting an increase in mean and maximum lifespan measures relative to untreated control animals in that specific tested strain (Anisimov VN, et al., PMID 12946225). This and related published animal-model research is preclinical and specific to the tested strains and conditions; it does not establish efficacy in humans and should not be interpreted as clinical or longevity evidence for people.

Pineal-Gland and Neuroendocrine Signaling Research

Separate published research has examined Epitalon’s proposed influence on melatonin synthesis and broader neuroendocrine signaling, consistent with its origin as a synthetic model of a pineal-gland extract.

What the Human Evidence Shows

Researchers evaluating Epithalon should know that the published literature on this specific tetrapeptide includes both preclinical (animal and in vitro) research and a body of Russian-published clinical research on related Khavinson-group pineal and thymic bioregulator peptides, conducted under Russian regulatory and publication standards distinct from Western (FDA/EMA) randomized-controlled-trial design. Researchers should take particular care to distinguish published clinical research on other, chemically distinct Khavinson bioregulator compounds (such as Thymalin) from research specific to Epithalon itself, since these are related but separate compounds within the same research tradition.

Epithalon is not an FDA-approved drug for any indication, has not completed a Western regulatory clinical-trial pathway, and is not evaluated by the FDA for safety or efficacy in humans or animals under this research-use-only sale. Researchers should characterize Epithalon findings accordingly in any grant application or protocol design, citing only the specific compound and study design directly relevant to their research question.

Frequently Asked Questions

What is the purity of this Epithalon research peptide?
Every batch is independently verified via third-party HPLC and mass-spectrometry testing, with a Certificate of Analysis published for each lot.

How should Epithalon research peptide be stored?
Store the lyophilized powder at −20°C. After reconstitution, refrigerate at 2–8°C and use within 4–6 weeks; avoid repeated freeze-thaw cycles.

Is Epithalon approved for human or animal use?
No. Epithalon is not an FDA-approved drug for any indication and has not completed a Western regulatory clinical-trial pathway. It is sold exclusively for in vitro and laboratory research use.

What is the proposed mechanism of Epithalon in research models?
The most substantiated proposed mechanism is modulation of telomerase activity and telomere length, reported in tested human cell lines. Additional proposed mechanisms include melatonin-pathway and neuroendocrine signaling effects, studied primarily in animal models.

Has Epithalon been tested in animal lifespan models?
Yes. Published research in female SHR mice reported increased mean and maximum lifespan measures following subcutaneous Epithalon administration (PMID 12946225). This is preclinical, strain-specific animal research and does not establish any effect in humans.

What does the Certificate of Analysis show?
The Certificate of Analysis published for each batch shows the HPLC purity result, mass-spectrometry molecular-weight confirmation, lot number, and test date, allowing researchers to independently verify the identity and purity of the specific batch they receive.

Can Epithalon research peptide be shipped internationally?
Shipping availability and any import restrictions for research peptides vary by destination country and are subject to change; researchers should confirm their local import regulations for research-use-only compounds before ordering.

Shipping, Handling & Compliance

This Epithalon research peptide ships as a lyophilized powder in a sealed glass vial, packaged to maintain cold-chain integrity in transit where applicable. All orders are subject to the research-use-only terms stated on this page, and First Class Science does not sell this or any other research peptide for human or veterinary administration under any circumstance.

Order tracking, batch-specific documentation requests, and general product questions can be directed to First Class Science customer support, which can confirm current lead times and any destination-specific documentation a receiving institution may require for its own compliance records.

Disclaimer: The research summarized above is drawn from third-party published studies conducted in animal, in vitro, or non-U.S. clinical contexts. It is provided for research and educational reference only and does not describe an intended use, effect, or benefit of this product for any person or animal.

⊗ ALL ITEMS ARE SOLD FOR RESEARCH USE ONLY. This category covers strictly in vitro laboratory testing and scientific experimentation. Content on this site is for education only and does not authorize human or animal use of any kind, which is prohibited by law. Only trained, licensed professionals should handle these materials. Nothing sold here qualifies as a drug, food, or cosmetic, and none of it may be labeled, advertised, or used as such.